South Africa’s Supreme Court reverses approval of Monsanto’s GMO maize after a nine-year battle led by the African Center for Biodiversity, citing unaddressed safety concerns. This landmark ruling is the first on GMOs in South Africa, exposing the approval of GMOs without thorough health and environmental impact assessments. The decision raises crucial questions about the regional impact of GMOs on African nations reliant on South African imports and sets a precedent for greater scrutiny on GMO safety across the continent.